Shunt flow - Qp:Qs
- Qp:Qs > 1.5 = hemodynamically significant left-to-right shunt.
- Qp:Qs > 2 in unrepaired ASD/VSD strongly favors closure (in absence of Eisenmenger physiology).
- Qp:Qs < 1 suggests reversed (right-to-left) shunt.
Direct visualization of shunts
- VSD: color Doppler across the septum (mosaic, high-velocity). Small restrictive VSDs have high velocity gradient (LV pressure ≫ RV pressure). Large unrestrictive VSDs equalize pressures → low-velocity flow.
- ASD: color Doppler across the atrial septum, usually low-velocity. Best on subcostal view (perpendicular to septum). Agitated saline for bubble study (right-to-left shunt).
- PDA: color Doppler in the descending aorta showing continuous flow into the PA at the level of the left pulmonary artery origin.
Pressure gradient across a shunt
- ΔP = 4v² (modified Bernoulli).
- Small restrictive VSD: peak systolic v ~4–5 m/s → ΔP ~80–100 mmHg → LV-RV pressure difference.
- Large unrestrictive VSD (Eisenmenger): pressures equalize → low velocity.
RV pressure from a VSD jet
- RV systolic pressure = SBP (LV systolic) − (4 × VSD peak velocity²).
- Requires no LVOT obstruction.
Pulmonary vein flow in ASD
- With significant L-to-R shunt: increased pulmonary venous return, dilated pulmonary veins.
Qp:Qs from oximetry (invasive, cath lab)
- Qp:Qs = (SaO₂ − MVO₂) / (PVO₂ − PAO₂), where MV = mixed venous saturation, PV = pulmonary vein.