Anatomy
- Three leaflets: anterior (largest), septal (smallest), posterior.
- Best imaging views: apical 4-chamber (septal + anterior leaflets), RV inflow (anterior + posterior), PSAX at AV level (septal + anterior).
- Tricuspid annulus dilation: > 40 mm (or 21 mm/m²) at end-diastole → likely severe primary or functional TR.
Physiologic TR
- Nearly universal on echo (present in > 70 % of normal adults). Only mild trivial flow.
Etiology of TR
Primary (leaflet abnormality):
- Rheumatic (usually with concomitant mitral disease).
- Endocarditis (IVDU; septal leaflet close to a VSD).
- Ebstein's anomaly.
- Carcinoid (metastatic disease to liver): thickened, retracted, immobile leaflets → both stenosis and regurgitation.
- Radiation.
- Traumatic (leaflet flail after chest trauma).
- Prolapse (part of myxomatous disease).
- Pacemaker/ICD lead impingement.
Secondary (functional):
- Annular dilation from RV or RA enlargement (pulmonary hypertension, AF, ischemic MR with LV dilation).
TR quantification - severe criteria (ASE 2017)
- Vena contracta width ≥ 0.7 cm.
- EROA (PISA) ≥ 0.40 cm².
- Regurgitant volume ≥ 45 mL/beat.
- Systolic hepatic vein flow reversal.
- Dense CW envelope with early peaking, triangular appearance ('V wave cut-off').
- Enlarged RA, RV, IVC (chronic).
Massive TR / torrential TR
- Extended grading: VC > 1.4 cm (massive), > 2.1 cm (torrential).
- Increasingly recognized in advanced heart failure and long-standing AF.
Pulmonary artery pressure from TR jet
- PASP = 4·(TR V_peak)² + RA pressure.
- RA pressure estimated from IVC:
- Normal RA pressure (~3 mmHg): IVC ≤ 2.1 cm and collapses > 50 % with sniff.
- Elevated (~15 mmHg): IVC > 2.1 cm and collapses < 50 %.
- Intermediate (~8 mmHg): one criterion but not the other.
Mean PAP from PR
- Mean PAP ≈ 4·(early diastolic PR velocity)².
- PA end-diastolic pressure ≈ 4·(end-diastolic PR velocity)² + RAP.
Carcinoid heart disease
- Metastatic mid-gut carcinoid → serotonin bypass through PFO or right-sided involvement.
- Right heart lesions (TV + PV): thickened, retracted, immobile leaflets → mixed TR/TS and PR/PS.
- Left heart involvement only if there is a right-to-left shunt (PFO) or a primary bronchial carcinoid.
Surgical thresholds
- Symptomatic severe TR: valve surgery.
- Progressive RV dilation / dysfunction with severe TR.
- At time of left-sided valve surgery: repair TR if severe, or if tricuspid annulus > 40 mm even with mild-moderate TR.